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Additionally, GLP-1 receptor activation in the central nervous system reduces appetite and food intake, slows gastric emptying, and promotes satietymechanisms that contribute to both glycemic control and weight reduction

Myostatin deficiency has been studied in many species including mice, dogs, sheep, cattle and humans 46,47,48,49,50

doi: 10.4236/ojpathology.2018.81004 51

This reversal of the LDH reaction in hepatocytes diverts pyruvate from gluconeogenesis leading to a reduction in the capacity of the liver to deliver glucose to the blood