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The 4-PBA group showed mild sinusoidal congestion with focal hepatocyte necrosis as manifested by nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia (Figure 8A), yet it significantly attenuated histopathological scoring compared to MTX-group (Figures 8BD)

1 Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to joint swelling, joint pain, morning stiffness, joint deformities, osteoporosis, and even disability ( + T cells, and macrophages, along with early activation of stromal cells

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