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Green tea polyphenols can decrease the absorption of lipids and proteins in the intestine and thus can reduce calorie intake (Reference Yang, Zhang and Zhang51)

doi: 10.1074/jbc.M109037200 254 HollandWLMillerRAWangZVSunKBarthBMBuiHHet al

Caffeine inhibits activation of the NLRP3 inflammasome via autophagy to attenuate microglia-mediated neuroinflammation in experimental autoimmune encephalomyelitis

In fact, the rapid physiological changes that come with significant weight loss can challenge mental health in ways that even seasoned psychiatrists sometimes underestimate