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Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats

A 2025 nutrition review found that high-protein breakfasts reduced afternoon hunger by almost twenty-five percent compared with carbohydrate-heavy ones

When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before

As expected, UACR fell by 34% in the finerenone group vs 12% in the placebo group, translating to a 25% greater fall with nsMRA treatment