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At the gene expression level, ZEB1, SIRT1, and CD16 mRNA levels were increased following 5MQ treatment, while TWIST and SERPIN1 mRNA levels were reduced

The function of the fatty-acid oxidation pathway in fibroblast cultures and biomarkers for abnormalities in non-mitochondrial fatty-acid metabolism were not consistently abnormal across the subgroup of ASD children, consistent with the notion that the abnormalities in fatty-acid metabolism found in this subgroup of children with ASD were secondary to TCAC abnormalities

Klotho plays a crucial role in modulating FGF23 signaling and its effects on target tissues, primarily the kidneys (109)