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Consistent with the distribution of Firmicutes in the cecal samples, the relative abundance of Ileibacterium was highest in the WD controls (average relative abundance 68%), second highest in the LD controls (average relative abundance 51%), and lowest in the vehicle- and 5A-1MQ-treated mice switched from WD to LD (average relative abundances of 40% and 41%, respectively)

While GLP-1based therapies directly influence appetite and glucose metabolism, peptides like BPC-157 may operate more indirectly by supporting tissue health and inflammation control

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This energetic crisis is compounded by a 45% decline in mitochondrial membrane potential while ROS production increases 3.4-fold, creating a cascade of cellular damage (51)