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From 2004 to 2009, an analysis of the database revealed a six-fold increase in pancreatitis incidents linked to the DPP-4 inhibitor sitagliptin and the GLP-1 mimetic exenatide, the first two GLP-1-based medications marketed in the US [51]

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The standard retatrutide dose schedule from clinical trials The phase 2 trial published in the New England Journal of Medicine tested multiple dosing arms, and the data from these arms forms the foundation of every retatrutide dose schedule used today

The underlying mechanisms of GLP-1 receptor agonism make these medications particularly suited to addressing both conditions simultaneously