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In the context of EDC, elevated LPS levels caused by gut microbiota dysbiosis can be considered a third hit. Building upon existing central pathologies, this third hit exacerbates neuroinflammation, synergistically worsening both epileptic seizures and depressive symptoms, thereby perpetuating a vicious cycle (Arora et al., 2022)

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All of these can lead to unreliable research results, wasted materials, and compromised experimental integrity

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications