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Furthermore, by comparing different populations with different grades of exposures, major disease determinants can be uncovered that would otherwise remain undetected, if the suspected risk factors show only little variation within a single population (Rose, 1985)

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Weighted gene co-expression network analysis identified modules altered in directions opposite to aging and enriched for hallmarks of aging processes including cellular senescence, oxidative phosphorylation, proteostasis, lysosome autophagy mitophagy, and inflammatory responses