In addition, gene therapy can enhance cellular antioxidant capacity by upregulating the expression of antioxidant enzymes, thus reducing ROS accumulation
Legrand-Abravanel F, Claudinon J, Nicot F, Dubois M, Chapuy-Regaud S, Sandres-Saune K, Pasquier C, Izopet J
The second co-stimulatory signal arises from the engagement of B7.1 (CD80) and B7.2 (CD86) molecules on APCsincluding activated macrophages, dendritic cells, and B cellswith CD28 on T cells
Too much variation in either direction creates problems: Doses too far apart (9+ days): blood levels drop below the therapeutic threshold, reducing appetite suppression and glucose control Doses too close together (5 days or less): blood levels climb higher than intended, increasing nausea, vomiting, and other GI side effects The question "can I take it a day early" is really asking: how much timing flexibility exists before I create one of those two problems