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These conditions might facilitate continual re-stimulation of GLP-1R to maintain the ongoing insulin release, as suggested by the trajectory of insulin accumulation in Fig

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Rather than dismissing or criticizing patients for their choices, clinicians should objectively evaluate potential risks, verify exactly what the patient is taking, and develop a safe, evidence-based treatment plan that preserves trust while strengthening the therapeutic relationship

Ensuring Adequate Micronutrient Intake: Individuals on GLP-1 therapy with reduced appetite and food intake, need to ensure they are getting the right macronutrients (protein, carbohydrates, fats and fibre) and micronutrients (essential vitamins and minerals)