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Animal Model Evidence The systemic evidence base is entirely preclinical: Pulmonary fibrosis (mouse model): Intraperitoneal GHK-Cu at 0.2-20 micrograms/g/day protected against bleomycin-induced lung fibrosis by inhibiting TGF-beta1/Smad signaling and reducing oxidative stress (PMID 31809714)

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Although there has been no direct head-to-head study comparing between the two preparations of semaglutide, the SUSTAIN-1 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide against placebo in 387 T2D patients using a similar study design and patient population to PIONEER-1

Proponents say these new-generation weight-loss drugs are a significant new tool in the battle against obesity