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Weeks 13+: 10-12 mg per week (maintenance) The highest clinical doses

Each plot shows the marginal probabilities for signal peptide regions

At 24 weeks, average weight loss was: At 48 weeks, average weight loss was: The study also found that, at 48 weeks, 100% of people taking 12mg lost at least 5% of their body weight , 93% lost at least 10% , and 83% lost at least 15%

Tirzepatide and retatrutide have many similar potential side effects, including: nausea diarrhea constipation acid reflux decreased appetite Anyone on a weight loss med should be monitored by a clinician, who can keep an eye on your progress and help you navigate common side effects