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The incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP, formerly known as gastric inhibitory peptide)

There was a whole Rick and Morty episode about having your body workout automatically while youre asleep (though that spiraled into the night versions trying to take over the day, but it's the same idea.) Today, telling newly diagnosed Type 2 Diabetics to exercise and lose weight rarely ever works (though that would reverse their condition in many cases) - so they start on Metformin, then more drugs, then diabetic foot needs to be surgically managed, wound cleaned, kidney problems, etc

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A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins