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De Jonghe et al., Motor disturbances/hypoactivity Another concern with therapies targeting the mesolimbic system is that the behavioral outcomes obtained are not specific to ingestive behavior and mediated via a general increase or decrease in physical activity

Scientists consider B cells to act as primary producers of antibodies against foreign and invasive cell structures

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Importantly, they also illustrate how defects at distinct levels of the UPS, substrate recognition, ubiquitin recycling or proteasome targeting, can converge on a common outcome of proteotoxic stress and neurodegeneration