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This damage is due to the glycosylation of proteins like collagen and elastin in the connective tissue of the lungs that leads to cross-linking, making collagen more resistant to degradation, and potentially contributing to airway remodeling [11]

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The subfamily is distinguished from the others by the presence of a long C-terminal extension immediately downstream of the C2 domain, which is required for activation by G q subunits, and which plays a role in plasma membrane binding and nuclear localization

This can make it harder to meet needs for nutrients like iron, B12, folate, calcium and vitamin D, especially if you already had a low intake or follow a restrictive diet, so monitoring and targeted supplements may be needed