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GLP-1 medications can be a valuable tool in this process, but a holistic approach, tailored to your individual needs and circumstances, is essential

doi: 10.3389/ftox.2026.1752511 Received 24 November 2025 Revised 30 December 2025 Accepted 08 January 2026 Published 16 January 2026 Volume 8 - 2026 Edited by Konrad Andrzej Szychowski, University of Information Technology and Management in Rzeszow, Poland Reviewed by Sanjiv Karale, Dr

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Practical recommendations for safe concurrent use include: Take melatonin exactly as prescribed by your doctor (typically Circadin 2mg modified-release tablet) Take melatonin at a consistent time each evening to support circadian rhythm regulation Monitor for any unusual side effects, particularly increased drowsiness or gastrointestinal symptoms If you have diabetes, check blood glucose levels more frequently when first combining these medicines Maintain a sleep diary to track whether melatonin is effectively improving your sleep quality Melatonin may cause drowsiness