retatrutide triumph 15 month update Triumph-1(retatrutide obesity trial) : r/Zepbound 🚨The first phase 3 retatrutide

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In animal experiments, it has been demonstrated that the endogenous GLP-1 receptor system is involved in the control of fluid intake and that, unlike food-generated stimuli, both endogenous GLP-1 and exogenous GLP-1 Ras inhibit fluid intake by activating the central nervous system GLP-1 receptor ( In previous real-world studies of GLP-1 RAs-induced hypoglycemia, lixisenatide showed the strongest association (Figure 2)

Below is a summary of key published data points researchers should reference when evaluating these two compounds

In clinical trials, tirzepatide helped participants lose an average of 20% of their body weight after 72 weeks significantly more than semaglutide, which averaged around 15%