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Following a review completed in 2024, the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) concluded that available evidence did not support a causal link between GLP-1 receptor agonists and suicidal ideation or self-harm, a conclusion also reflected in MHRA communications that year
However, whether GLP-1RA induces pancreatitis or pancreatic cancer by affecting the expression level of related genes in the pancreas or by regulating the secretion of pancreatic enzymes is still inconclusive
It overlaps with both but isnt identical to either
Figure 1: A medieval urine wheel from Epiphanie Medicorum, a medical textbook printed in Nuremberg, Germany in c.1506 by Ullrich Pinder
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