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The aged mice exhibited a longer healthspan, exerted greater physical activity, and researchers observed less disability such as cardiac diseases and musculoskeletal dysfunction, etc

Peer review Peer review information Nature Metabolism thanks Alice Adriaenssens, Nigel Irwin and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

In agreement with the noncompetitive behavior of 9 and as determined by structural superposition of the cryo-EM structure and the X-ray NADPH-TGR- complex 17 , inhibitor 9 does not sterically interfere with NADPH binding

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