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Using recommended dosing conditions for oral semaglutide, mean bioavailability was estimated at approximately 0.8% (0.795% [95% confidence interval 0.7360.864]) (Table 1 of the ESM)

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This combination therapy results in increased activation of CD8 + T cells and CD86 + dendritic cells in the spleen, leading to elevated levels of pro-inflammatory cytokines [206]