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FDA approves Novo Nordisks oral semaglutide (Rybelsus) for CV risk reduction in T2DM adults owenhaskins Oct 20, 2025 3 min read Novo Nordisk has received FDA approval for Rybelsus for reducing the risk of major adverse cardiovascular events (MACE) such as cardiovascular (CV) death, heart attack, or stroke in adults with type 2 diabetes who are at high risk for these events, whether they've had a prior CV event or not (primary and secondary prevention)