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doi: 10.1016/j.apnu.2014.11.008 57 ReizineFLesouHaitierMGregoireMPinceauxKGacouinAMaamarAet al

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Activation of the contractile apparatus is responsible for the loss and disorganization of dense tight junction (TJ) proteins, which consecutively lead to BBB breakdown (60)

They may also reduce the effectiveness of doxycycline and minocycline, other antibiotics in the tetracycline class of antibiotics, according to StatPearls