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Further, NASO B12 was well-tolerated throughout the treatment period.[] Patients on metformin therapy receiving NASO B12 should also be instructed that they will require weekly intranasal administration of NASO B12 spray in each nostril after correction of vitamin B12 deficiency for the remainder of their lives

Sterile water contains no preservative, so the solution is only considered sterile for about 24 hours after the first puncture

Vitamin B12 Serum Trough Levels After Intramuscular Solution (IM) of 100 mcg and Nasal Gel (IN) Administration of 500 mcg Cyanocobalamin After Weekly Doses

This pharmacological profile creates a dose-dependent weight loss curve that, in clinical trials, reached 24.2% at the 12mg weekly dose over 48 weeks and an astonishing 28.7% at 12mg over 68 weeks in the TRIUMPH-4 phase 3 trial