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Investigations of side effects become especially important given the broad range of people this medicine and others like it could help. The authors of the study note some limitations, including the predominantly white male population, and that analysis of MACE outcomes according to post-randomisation changes in weight or waist circumference within the treatment groups is subject to confounding and therefore cannot prove causation or define mechanisms.

Exercise: Regular physical activity increases blood flow to the brain and stimulates neurogenesis

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