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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Punjabi N.M., Caffo B.S., Goodwin J.L., Gottlieb D.J., Newman A.B., OConnor G.T., Rapoport D.M., Redline S., Resnick H.E., Robbins J.A., et al

Side effects can be managed through dietary modifications (smaller meals, avoiding high-fat foods), adherence to dose escalation schedules, and appropriate hydration

P53 phosphorylation at Ser15 was confirmed to enhance the affinity for both FOXO4 and FOXO4-DRI, providing a structural explanation for FOXO4-DRIs preferential engagement with the hyperphosphorylated p53 that characterises senescent cells