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A., Sauchi, Y., & Ito, H

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First, topiramate reduces the duration of abnormal discharges and the number of action potentials within each discharge

287,293 Paralleling findings in humans, findings from several established animal models of ASD, including offspring with maternal immune activation (MIA) (IL2, IL6 and IL17) 294,295,296 and offspring of VPA-treated rodents (TNF- and IL-6), 297 and the naturally occurring BTBR strain (IL-33, IL-18, IL-1 and CXCL7) 298,299 have also shown alterations in the secretion of cytokines and chemokines