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These characteristics make GLP-1 a promising therapeutic target, with several strategies developed to enhance its effects

The results paved the way for liraglutide, branded as Saxenda, to be approved in the US as a once-a-day subcutaneous injection in December 2014 and in Europe in 2015 for the treatment of chronic weight management combined with a reduced calorie diet and increased physical exercise (Molteni, Chen)

Starting at the full dose can cause severe nausea, vomiting, and other gastrointestinal effects that may force you to stop again

Gastric clearance and satiety : GLP-1 slows the emptying of the stomach, thus extending post-meal satiety and reducing the pace at which glucose penetrates into the bloodstream