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Carnitine synthesis requires gamma-butyl betaine hydroxylase, and premature infants have a limited capacity to synthesize L-carnitine themselves, having only 1215% of the synthesis ability of adults ( 3.2 L-carnitine levels in preterm infants Due to the large transfer of maternal L-carnitine to the fetus in the third trimester and the immature mechanism of carnitine transport in premature infants, the blood level of l-carnitine in premature infants after 3 to 7 days is slightly higher than that in full-term infants ( Consequently, despite the potential for higher initial blood levels, the inherent physiological immaturity and reduced somatic mass associated with preterm birth mean that these infants have significantly diminished endogenous L-carnitine reserves

Shaw RA, Crane J, O'Donnell TV, Lewis ME, Stewart B, & Beasley R (1992a) The use of a videotaped questionnaire for studying asthma prevalence: A pilot study among New Zealand adolescents

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Similar results were obtained in patients receiving amlodipine besylate and concomitant beta-blockers