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Estrogen: Protecting Womens Curves, Metabolism & Long-Term Weight Stability Learn How Estrogen Affects Weight Loss For women, estrogen prevents: unwanted fat loss in the breasts, hips, and buttocks facial fat loss that leads to Ozempic Face, Zepbound Face, or the gaunt look caused by rapid loss of facial fat (GLP-1 Face), or premature aging muscle loss that slows metabolism thyroid sluggishness rapid rebound weight gain after tirzepatide and semaglutide Estrogen keeps a womans metabolism youthful, stable, and resilient