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In a male murine binge-on-chronic alcohol model, we confirm gut microbial reorganization, elevation in PAGln levels, and the presence of cardiovascular pathophysiology

These data, together with our findings, suggest that dose adjustment of CagriSema is unlikely to be needed in people with renal or hepatic impairment

Additional roles of ALDH2: In addition to breaking down alcohols, ALDHD also metabolizes:[ref] Retinol (vitamin A) Bile acids lipid peroxidation products neurotransmitter metabolites Studies link genetic variants in ALDH2 to increased risk of Alzheimers disease, possibly due to the decreased ability to break down lipid peroxidation products in the brain