Glutathione deficiency contributes to oxidative stress which leads to early aging and many diseases including liver disease, cardiovascular disease, and diabetes
The blood flow may also deliver more nutrients to the muscle tissue
Egunsola AT, Bae Y, Jiang MM, Liu DS, Chen-Evenson Y, Bertin T, Chen S, Lu JT, Nevarez L, Magal N, Raas-Rothschild A, Swindell EC, Cohn DH, Gibbs RA, Campeau PM, Shohat M, Lee BH, "Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia", The Journal of clinical investigation 127 (4): 1475-1484 (2017)
When the annulus tears or weakens, the nucleus can bulge or herniate, potentially compressing spinal nerves