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Sage (Salvia officinalis) is a plant of Iranian origin that is rich in phytochemicals like Rosmarinus acid and flavonoids by this, it can help to control glucose metabolism and insulin sensitivity

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For severe liver damage, high doses are recommended to optimise treatment outcomes

5-Amino-1MQ was developed as a pharmacological tool to inhibit NNMT activity, and preclinical studies have demonstrated that oral administration of 5-Amino-1MQ to obese rodents produces dose-dependent reductions in body weight and fat mass, improvements in glucose metabolism and insulin sensitivity, and increases in energy expenditure - remarkably, these effects occur without changes in food intake, indicating that 5-Amino-1MQ works through metabolic enhancement and increased caloric burn rather than appetite suppression