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Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on the plasma PAA to PAGN ratio
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Multi-omics approaches, including metagenomics, metabolomics, bile acid profiling, transcriptomics, and immune phenotyping, will be essential to identify microbial pathways associated with improved adiposity, inflammation, and therapeutic response