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Elucidating the spatiotemporal regulation of IGF signaling and its crosstalk with key profibrotic and inflammatory pathways may provide critical insights into disease heterogeneity and progression

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Gut-brain axis and addictive disorders: a review with focus on alcohol and drugs of abuse

1 Introduction Sepsis-associated encephalopathy (SAE) represents a severe complication of sepsis, defined by diffuse brain dysfunction without direct central nervous system (CNS) infection (Young et al., 1990) and the overall mortality rate remains high at 25%50%, despite advances in critical care