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After phase I and phase II, Tac is metabolized into at least 8 different products (21), potentially involved in mechanisms of Tac toxicity (22)

Important safety considerations during the initial treatment period include: Monitoring for severe gastrointestinal symptoms: Persistent vomiting, severe abdominal pain, or signs of pancreatitis (severe upper abdominal pain radiating to the back) require immediate medical evaluation

This mechanism involves the conversion of Phosphatidylinositol-4,5-bisphosphate (PIP2) to Phosphatidylinositol-3,4,5-trisphosphate (PIP3), facilitating Akt activation by membrane translocation and phosphorylation by PIP3-dependent kinases