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Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1) governs this process by activating multiple transcription factors, including nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2) and mitochondrial transcription factor A (TFAM) (46)
Mechanistically, ferroptosis is driven by the accumulation of lethal phospholipid hydroperoxides (PL-OOH), primarily derived from polyunsaturated fatty acid (PUFA)-containing phospholipids
It is studied in sleep physiology, stress response, neuroendocrine regulation, and antioxidant activity research
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