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If fatigue is severe, sudden, or unexplained, bring it to your clinician B12 is one possible factor, but it's not the only one worth ruling out

Patients experiencing new-onset lower back pain while taking semaglutide should not automatically attribute the symptom to their medication, as alternative explanations are often more likely and require appropriate clinical evaluation

[Abstract] Am J Pathol

GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors