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PMID: 18728662

2 Mechanisms of Parkinsons disease The aetiology and pathogenesis of PD involve abnormal aggregation of -synuclein (-syn), mitochondrial dysfunction, oxidative stress, and neuroinflammation (Figure 1)

104,105,106 Over a decade ago, an in vitro study revealed that a combination of specific transcription factorsGATA4, MEF2C and TBX5 (collectively referred to as the GMT cocktail)could directly reprogram fibroblasts into functional cardiomyocytes, bypassing the conventional iPSC stage

However, since this method does not guarantee complete polarity reversal, distinguishing between apical and basolateral interactions is difficult