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The patient developed rapid heart and respiratory rates, headaches, and night blindness, and ultimately became comatose

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Some studies suggest that OCTN1 mediate the uptake of a mushroom metabolite named ergothioneine, which probably exerts an anti-oxidant function in tissues exposed to ROS (Pochini et al., 2012, 2016), a ubiquitous pathway that modulates several cell functions, among which inflammation (Pochini et al., 2015, 2016)

The step requirement can be waived with documented contraindication, intolerance, or insufficient response