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Lilly is studying retatrutide in several phase 3 clinical trials to evaluate its potential efficacy and safety across several indications, including obesity and overweight with 1 weight-related medical problem, type 2 diabetes, knee osteoarthritis, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatotic liver disease

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The modifications reduce IGFBP binding by approximately 90%, increasing free bioavailable peptide