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This highlights the complexity of GPCR activation, where downstream signalling is influenced by the interplay of multiple transducers that can interact with activated receptors (pleiotropic coupling), and can also be influenced by different trafficking profiles that alter the location of the receptor in the cell

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In 90% of melasma cases, the use of sunscreen is inadequate, this needs rectifying prior to any antioxidant therapy

Low blood sugar (hypoglycemia): Risk increases when used with insulin or sulfonylureas