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Current Evidence Gaps No direct head-to-head randomized controlled trials comparing Retatrutide and Cagrilintide monotherapy exist in the published literature

Despite major advances in the field concerning the neurobiological substrates underlying the ES-induced increased risks for adverse neurobehavioral outcomes and psychopathology, the underlying mechanisms remain complex, multi-faceted, not yet completely understood and often hard to target, rendering the development of effective interventions challenging [8, 9]

He says his patients have been frustrated and disappointed by the prohibitive cost