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675 Targeting Nrf2 has also become a research hotspot in TBI therapy due to its capacity to reduce oxidative stress and inhibit ferroptosis
However, other randomized controlled trials have not found any benefit of citicoline treatment in the management of acute ischemic stroke (98, 99), including a recent trial evaluating its effects when provided immediately following endovascular thrombectomy (i.e., recanalization therapy) and continued for 42 days (100)
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