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Notes Notes Authors contributions Conceptualization: VT, VB Investigation: SV, PS, SK Writingoriginal draft: SV, PS, SK, VT, VB Writingreview & editing: All authors All authors read and approved the final manuscript

Studies in animal models with gut microbiota depletion have shown increased plasma tryptophan, elevated brain serotonin concentrations, and reduced kynurenine pathway activity, all of which normalize following microbiota restoration (229231)

Opiate Detox Process The opiate detox process is not the same as detoxing from other addictive substances, such as alcohol or cocaine