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Subsequent clinical success demonstrated that these liabilities could be mitigated through slower absorption kinetics, extended dosing intervals, and careful titration, ultimately allowing the beneficial metabolic effects to dominate the riskbenefit profile (Drucker, 2018

J Affect Disord 325:313320 Westin MA, Hunt MC, Alexson SE (2008) Short- and medium-chain carnitine acyltransferases and ACYL-COA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes

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Despite of these findings, most findings regarding the neuroprotective effects of TRZ are obtained from preclinical studies that have not been completely translated into clinical settings