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These aimed to capture more clinically realistic treatment intensification patterns, as per NICE guidelines, but were associated with significant uncertainty regarding changes in risk factors at each intensification step [11]

doi: 10.3389/fendo.2020.608428 Received 20 September 2020 Accepted 08 December 2020 Published 26 January 2021 Volume 11 - 2020 Edited by Ilaria Muller, Fondazione IRCCS Ospedale Ca Granda Maggiore Policlinico, Italy Reviewed by Giampaolo Papi, Local Health Unit of Modena, Italy

Monitoring and Follow-up Regular follow-ups (weekly or biweekly initially, then monthly) to assess response, side effects, adherence

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