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Statistical parameters were calculated using the Design Expert program version (13.0.5.0, Stat-Ease Inc., USA) (Singh et al

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The obtained retention indices (RIs) were compared to those in the online NIST library and the literature to determine the compositional identity ( 2.5 Molecular docking study The three-dimensional X-ray structures of human CAT and the transforming growth factor- (TGF- ) receptor were retrieved from the Protein Data Bank under the IDs 8hid and 6b8y, respectively