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Mean follow-up time was longer for cohort 2 than for cohort 1

Early weight loss can begin, though it is typically modest

Our findings expand the opportunity to treat patients who have overweight or obesity and existing heart disease without Type 1 or Type 2 diabetes, and we have a chance to significantly reduce their risk of a secondary cardiovascular event including death. The trial only included adults with prior cardiovascular disease, therefore, it did not investigate primary prevention of cardiovascular disease (people with no history of a heart attack, stroke and/or peripheral artery disease)