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Growth hormone deficiency is associated with longer lifespan, and high levels of growth hormone and IGF-1 are linked to shorter lifespan, as seen in species like dogs where larger breeds with higher IGF-1 levels have shorter lifespans than smaller breeds 10s

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These include, extreme tiredness, a lack of energy, pins and needles, muscle weakness, disturbed vision, mouth ulcers, a sore and red tongue, and cognitive or psychological concerns such as depression, confusion, and difficulty with memory, understanding or judgement